Prognostic significance of pretreatment total lymphocyte count and neutrophil-to-lymphocyte ratio in extensive-stage small-cell lung cancer

We evaluated pretreatment total lymphocyte count (TLC, marker of immunosuppression), neutrophil-to-lymphocyte ratio (NLR, marker of inflammation), and overall survival (OS) in patients with extensive-stage small-cell lung cancer (ES-SCLC). Pretreatment blood characteristics, age, sex, performance st...

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Veröffentlicht in:	Radiotherapy and oncology 2018-03, Vol.126 (3), p.499-505
Hauptverfasser:	Suzuki, Ryoko, Lin, Steven H., Wei, Xiong, Allen, Pamela K., Welsh, James W., Byers, Lauren A., Komaki, Ritsuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Female Hematologic marker Humans Immune status Inflammation Lung Neoplasms - blood Lung Neoplasms - immunology Lung Neoplasms - pathology Lung Neoplasms - therapy Lymphocyte Count Lymphocytes - immunology Lymphocytes - pathology Male Middle Aged Neoplasm Metastasis Neutrophils - immunology Neutrophils - pathology Overall survival Percutaneous Coronary Intervention Prognosis Prognostic factors Proportional Hazards Models Retrospective Studies Small Cell Lung Carcinoma - blood Small Cell Lung Carcinoma - immunology Small Cell Lung Carcinoma - pathology Small Cell Lung Carcinoma - therapy
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Zusammenfassung:	We evaluated pretreatment total lymphocyte count (TLC, marker of immunosuppression), neutrophil-to-lymphocyte ratio (NLR, marker of inflammation), and overall survival (OS) in patients with extensive-stage small-cell lung cancer (ES-SCLC). Pretreatment blood characteristics, age, sex, performance status, race, stage (M1a vs. M1b), number and location of metastases, weight loss, smoking status, chemotherapy cycles (
ISSN:	0167-8140 1879-0887
DOI:	10.1016/j.radonc.2017.12.030