The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats

Apoptosis is increased in the liver in old age and is a common pathological feature of liver disease. The mitochondria play a key role in regulating apoptosis via the intrinsic death pathway. As the effect of aging on this pathway is unclear, we aimed to characterize the impact of aging on the hepat...

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Veröffentlicht in:	Experimental gerontology 2015-07, Vol.67, p.54-61
Hauptverfasser:	Mach, John, Huizer-Pajkos, Aniko, Kane, Alice, Jones, Brett, McKenzie, Catriona, Mitchell, Sarah J., de Cabo, Rafael, Cogger, Victoria C., Le Couteur, David G., Hilmer, Sarah N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - pathology Aging - physiology Animals Apoptosis Apoptosis - physiology Apoptosis Regulatory Proteins - metabolism Apoptosis Regulatory Proteins - physiology Cytosol - metabolism Intrinsic death pathway Liver Liver - metabolism Liver - pathology Male Mitochondria Mitochondria, Liver - metabolism Mitochondrial Proteins - metabolism Rats, Inbred F344
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Zusammenfassung:	Apoptosis is increased in the liver in old age and is a common pathological feature of liver disease. The mitochondria play a key role in regulating apoptosis via the intrinsic death pathway. As the effect of aging on this pathway is unclear, we aimed to characterize the impact of aging on the hepatic intrinsic death pathway and apoptosis. Livers from young adult (6.6±0.3months, n=9) and old (25.4±0.7months, n=9) male Fischer 344 rats were extracted for cellular fractionation and immunobloting. In old age there were lower mitochondrial protein levels of pro-apoptotic BAK, BID, tBID and VDAC1 (p
ISSN:	0531-5565 1873-6815
DOI:	10.1016/j.exger.2015.04.009