Host Transcription Profile in Nasal Epithelium and Whole Blood of Hospitalized Children Under 2 Years of Age With Respiratory Syncytial Virus Infection

RSV infection induces a clearly different host response pattern compared with hRV and induced strong innate immune responses both locally and systemically. B cell lymphoma (BCL6) is a hub gene that positively correlates with RSV load and disease severity. Abstract Background Most insights into the c...

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Veröffentlicht in:The Journal of infectious diseases 2017-12, Vol.217 (1), p.134-146
Hauptverfasser: Do, Lien Anh Ha, Pellet, Johann, van Doorn, H Rogier, Tran, Anh Tuan, Nguyen, Bach Hue, Tran, Thi Thu Loan, Tran, Quynh Huong, Vo, Quoc Bao, Tran Dac, Nguyen Anh, Trinh, Hong Nhien, Nguyen, Thi Thanh Hai, Le Binh, Bao Tinh, Nguyen, Huu Mai Khanh, Nguyen, Minh Tien, Thai, Quang Tung, Vo, Thanh Vu, Ngo, Ngoc Quang Minh, Dang, Thi Kim Huyen, Cao, Ngoc Huong, Tran, Thu Van, Ho, Lu Viet, De Meulder, Bertrand, Auffray, Charles, Hofstra, Jorrit-Jan, Farrar, Jeremy, Bryant, Juliet E, de Jong, Menno, Hibberd, Martin L
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Sprache:eng
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Zusammenfassung:RSV infection induces a clearly different host response pattern compared with hRV and induced strong innate immune responses both locally and systemically. B cell lymphoma (BCL6) is a hub gene that positively correlates with RSV load and disease severity. Abstract Background Most insights into the cascade of immune events after acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Methods In this study, we investigated host gene expression profiles in nasopharyngeal (NP) swabs and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalized patients
ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jix519