Endothelial Nitric Oxide Pathways in the Pathophysiology of Dengue: A Prospective Observational Study

Endothelial Nitric Oxide Pathways in the Pathophysiology of Dengue: A Prospective Observational Study

Dengue can cause increased vascular permeability that may lead to hypovolemic shock. Endothelial dysfunction may underlie this; however, the association of endothelial nitric oxide (NO) pathways with disease severity is unknown. We performed a prospective observational study in 2 Vietnamese hospital...

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Veröffentlicht in:Clinical infectious diseases 2017-11, Vol.65 (9), p.1453-1461
Hauptverfasser: Yacoub, Sophie, Lam, Phung Khanh, Huynh, Trieu Trung, Ho, Hong Hanh Nguyen, Thi, Hoai Tam Dong, Van, Nguyen Thu, Le Thi Lien, Ha, Quyen Nguyen Than, Le, Duyen Huynh Thi, Mongkolspaya, Juthathip, Culshaw, Abigail, Yeo, Tsin Wen, Wertheim, Heiman, Simmons, Cameron, Screaton, Gavin, Wills, Bridget
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
and Commentaries
Arginase
Arginase - blood
Arginase - metabolism
Arginine
Arginine - blood
Arginine - metabolism
ARTICLES AND COMMENTARIES
Bioavailability
Biomarkers
Biomarkers - blood
Biomarkers - metabolism
Dengue - blood
Dengue - epidemiology
Dengue - metabolism
Dengue - physiopathology
Dengue fever
Dengue hemorrhagic fever
Endothelium
Endothelium, Vascular - metabolism
Female
Fever
Humans
Leakage
Male
Nitric oxide
Nitric Oxide - blood
Nitric Oxide - metabolism
Observational studies
Patients
Permeability
Plasma
Plasma levels
Prospective Studies
Vasodilation
Vector-borne diseases
Viral diseases
Young Adult
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Zusammenfassung:Dengue can cause increased vascular permeability that may lead to hypovolemic shock. Endothelial dysfunction may underlie this; however, the association of endothelial nitric oxide (NO) pathways with disease severity is unknown. We performed a prospective observational study in 2 Vietnamese hospitals, assessing patients presenting early (
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cix567