Antimicrobial Resistance Gene Acquisition and Depletion Following Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection

Antimicrobial Resistance Gene Acquisition and Depletion Following Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection

Fecal microbiota transplantation (FMT) may be a novel approach to eliminate multidrug-resistant bacteria from the gut and to prevent future infections. Using whole metagenome sequencing data from 8 FMT donor-recipient pairs, we identified 37 and 95 antimicrobial resistance genes that were acquired b...

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Veröffentlicht in:Clinical infectious diseases 2018-01, Vol.66 (3), p.456-457
Hauptverfasser: Leung, Victor, Vincent, Caroline, Edens, Thaddeus J, Miller, Mark, Manges, Amee R
Format: Artikel
Sprache:eng
Schlagworte:
Antiinfectives and antibacterials
Antimicrobial agents
Antimicrobial resistance
Brief Reports
Drug resistance
Fecal microflora
Feces
Genes
Gram-positive bacteria
Medical procedures
Microbiota
Multidrug resistance
Recurrent infection
Transplantation
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Zusammenfassung:Fecal microbiota transplantation (FMT) may be a novel approach to eliminate multidrug-resistant bacteria from the gut and to prevent future infections. Using whole metagenome sequencing data from 8 FMT donor-recipient pairs, we identified 37 and 95 antimicrobial resistance genes that were acquired by or removed from FMT recipients, respectively.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/cix821