Extended release of proteins following encapsulation in hydroxyapatite/chitosan composite scaffolds for bone tissue engineering applications

•Biocompatible, mechanically robust scaffold with an appropriate stability for bone healing when used with fixation device•Proteins can be covalently attached to the scaffold•Proteins are released for an extended period under in vitro conditions

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Bibliographische Detailangaben
Veröffentlicht in:	Materials Science & Engineering C 2018-03, Vol.84, p.281-289
Hauptverfasser:	Devine, Declan M., Hoctor, Eilish, Hayes, Jessica S., Sheehan, Eoin, Evans, Christopher H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bearing capacity Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biomedical materials Biomimetics Bone and Bones - physiology Bone healing Bones Calorimetry, Differential Scanning Cell Line Cell Survival - drug effects Chitosan Chitosan - chemistry Composite materials Compressive Strength Durapatite - chemistry Fine structure Hydroxyapatite Materials science Mice Nanocomposites Proteins Scaffolds Serum Albumin, Bovine - chemistry Serum Albumin, Bovine - metabolism Spectroscopy, Fourier Transform Infrared Surgical implants Tissue Engineering Ultrastructure Wound healing
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Beschreibung
Zusammenfassung:	•Biocompatible, mechanically robust scaffold with an appropriate stability for bone healing when used with fixation device•Proteins can be covalently attached to the scaffold•Proteins are released for an extended period under in vitro conditions
ISSN:	0928-4931 1873-0191
DOI:	10.1016/j.msec.2017.11.001