Polygonumins A, a newly isolated compound from the stem of Polygonum minus Huds with potential medicinal activities

Polygonumins A, a new compound, was isolated from the stem of Polygonum minus . Based on NMR results, the compound’s structure is identical to that of vanicoside A, comprising four phenylpropanoid ester units and a sucrose unit. The structure differences were located at C-3″″′. The cytotoxic activit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2018-03, Vol.8 (1), p.4202-15, Article 4202
Hauptverfasser:	Ahmad, Rafidah, Sahidin, I., Taher, Muhammad, Low, ChenFei, Noor, Normah Mohd, Sillapachaiyaporn, Chanin, Chuchawankul, Siriporn, Sarachana, Tewarit, Tencomnao, Tewin, Iskandar, Faizah, Rajab, Nor Fadilah, Baharum, Syarul Nataqain
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 101/6 631/449/447 631/92/349 Adenocarcinoma Aquatic plants Colorectal cancer Colorectal carcinoma Cytotoxicity Free energy HIV Human immunodeficiency virus Humanities and Social Sciences Leukemia multidisciplinary NMR Nuclear magnetic resonance Paspalum minus Polygonum Proteinase inhibitors Science Science (multidisciplinary) Sucrose Tumor cell lines Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Polygonumins A, a new compound, was isolated from the stem of Polygonum minus . Based on NMR results, the compound’s structure is identical to that of vanicoside A, comprising four phenylpropanoid ester units and a sucrose unit. The structure differences were located at C-3″″′. The cytotoxic activity of polygonumins A was evaluated on several cancer cell lines by a cell viability assay using tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). The compound showed the highest antiproliferative (p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-018-22485-5