miR-216a-5p acts as an oncogene in renal cell carcinoma

miR-216a-5p acts as an oncogene in renal cell carcinoma

MiR-216a-5p has been acknowledged as an oncogene and is known to be involved in the progression and metastasis of numerous cancer subtypes. However, the potential role of miR-216a-5p in renal cell carcinoma (RCC) remains to be elucidated. In the present study, reverse transcription-quantitative poly...

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Veröffentlicht in:Experimental and therapeutic medicine 2018-04, Vol.15 (4), p.4039-4046
Hauptverfasser: Chen, Peijie, Quan, Jing, Jin, Lu, Lin, Canbin, Xu, Weijie, Xu, Jinling, Guan, Xin, Chen, Zebo, Ni, Liangchao, Yang, Shangqi, Chen, Yun, Lai, Yongqing
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Cancer therapies
Care and treatment
Development and progression
Gene expression
Genetic aspects
Health aspects
Kidney cancer
Kinases
Liver cancer
Metastasis
MicroRNA
MicroRNAs
Motility
Oncogenes
Pancreatic cancer
Prostate cancer
Renal cell carcinoma
Studies
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Zusammenfassung:MiR-216a-5p has been acknowledged as an oncogene and is known to be involved in the progression and metastasis of numerous cancer subtypes. However, the potential role of miR-216a-5p in renal cell carcinoma (RCC) remains to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reaction was performed to detect the expression levels of miR-216a-5p in RCC tissues. Cell counting kit-8, MTT, wound scratch, Transwell and flow cytometric assays were performed to establish the biological functions of miR-216a-5p in RCC. Functional experiments demonstrated that the expression of miR-216a-5p was upregulated in RCC (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.5881