Therapeutic effects of a taurine-magnesium coordination compound on experimental models of type 2 short QT syndrome

Short QT syndrome (SQTS) is a genetic arrhythmogenic disease that can cause malignant arrhythmia and sudden cardiac death. The current therapies for SQTS have application restrictions. We previously found that Mg· (NH 2 CH 2 CH 2 SO 3 )2· H 2 O, a taurine-magnesium coordination compound (TMCC) exert...

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Veröffentlicht in:	Acta pharmacologica Sinica 2018-03, Vol.39 (3), p.382-392
Hauptverfasser:	An, Meng-yao, Sun, Kai, Li, Yan, Pan, Ying-ying, Yin, Yong-qiang, Kang, Yi, Sun, Tao, Wu, Hong, Gao, Wei-zhen, Lou, Jian-shi
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - drug effects Animal models Animals Arrhythmia Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - prevention & control Biomedicine Cardiac arrhythmia Cardiac muscle Cells, Cultured Coordination Complexes - pharmacology Electrocardiography Guinea Pigs Heart Conduction System - abnormalities Heart Defects, Congenital - chemically induced Heart Defects, Congenital - prevention & control Heart diseases Humans Immunology Internal Medicine Magnesium Magnesium - chemistry Magnesium - pharmacology Medical Microbiology Models, Theoretical Myocytes Myocytes, Cardiac - physiology Original original-article Perfusion Pharmacology/Toxicology Pinacidil Pinacidil - antagonists & inhibitors Pinacidil - pharmacology Potassium Potassium channels (delayed-rectifying) Sulfur trioxide Taurine Taurine - chemistry Taurine - pharmacology Toxicity Trapidil - antagonists & inhibitors Trapidil - pharmacology Vaccine Ventricle
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Zusammenfassung:	Short QT syndrome (SQTS) is a genetic arrhythmogenic disease that can cause malignant arrhythmia and sudden cardiac death. The current therapies for SQTS have application restrictions. We previously found that Mg· (NH 2 CH 2 CH 2 SO 3 )2· H 2 O, a taurine-magnesium coordination compound (TMCC) exerted anti-arrhythmic effects with low toxicity. In this study we established 3 different models to assess the potential anti-arrhythmic effects of TMCC on type 2 short QT syndrome (SQT2). In Langendorff guinea pig-perfused hearts, perfusion of pinacidil (20 μmol/L) significantly shortened the QT interval and QTpeak and increased rTp-Te ( P
ISSN:	1671-4083 1745-7254
DOI:	10.1038/aps.2017.86