Prognostic value of tumor–stroma ratio combined with the immune status of tumors in invasive breast carcinoma

Purpose Complex interactions occur between cancer cells and cells in the tumor microenvironment. In this study, the prognostic value of the interplay between tumor–stroma ratio (TSR) and the immune status of tumors in breast cancer patients was evaluated. Methods A cohort of 574 breast cancer patien...

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Veröffentlicht in:	Breast cancer research and treatment 2018-04, Vol.168 (3), p.601-612
Hauptverfasser:	Vangangelt, K. M. H., van Pelt, G. W., Engels, C. C., Putter, H., Liefers, G. J., Smit, V. T. H. B. M., Tollenaar, R. A. E. M., Kuppen, P. J. K., Mesker, W. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Biomarkers, Tumor - blood Biomarkers, Tumor - immunology Breast cancer Breast carcinoma Breast Neoplasms - blood Breast Neoplasms - immunology Breast Neoplasms - pathology Cancer patients Cancer research Cytotoxicity Development and progression Disease-Free Survival Female Genes, MHC Class I - genetics Histocompatibility antigen HLA Histocompatibility Antigens Class I - blood HLA antigens HLA-E Antigens HLA-G Antigens - blood Humans Immune status Immunohistochemistry Invasiveness Killer Cells, Natural - immunology Lymphatic Metastasis Lymphocytes Lymphocytes T Mastectomy Medicine Medicine & Public Health Middle Aged Natural killer cells Neoplasm Invasiveness - immunology Neoplasm Invasiveness - pathology Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - immunology Neoplasm Recurrence, Local - pathology Oncology Preclinical Study Prognosis Statistical analysis Stroma Stromal Cells - immunology Stromal Cells - pathology T-Lymphocytes, Regulatory - immunology Tumors
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Zusammenfassung:	Purpose Complex interactions occur between cancer cells and cells in the tumor microenvironment. In this study, the prognostic value of the interplay between tumor–stroma ratio (TSR) and the immune status of tumors in breast cancer patients was evaluated. Methods A cohort of 574 breast cancer patients was analyzed. The percentage of tumor stroma was visually estimated on Hematoxylin and Eosin (H&E) stained histological tumor tissue sections. Immunohistochemical staining was performed for classical human leukocyte antigen (HLA) class I, HLA-E, HLA-G, markers for regulatory T (Treg) cells, natural killer (NK) cells and cytotoxic T-lymphocytes (CTLs). Results TSR ( P
ISSN:	0167-6806 1573-7217
DOI:	10.1007/s10549-017-4617-6