Oncological safety of nipple-sparing mastectomy in young patients with breast cancer compared with conventional mastectomy

Although nipple-sparing mastectomy (NSM) is being used more frequently, the oncological safety of NSM remains unclear, particularly in young patients (0.05). Following adjustment for clinical stage, the LR and DFS rates between the two groups exhibited no significant differences. Analysis of the pro...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncology letters 2018-04, Vol.15 (4), p.4813-4820
Hauptverfasser: Huang, Jiapeng, Mo, Qinguo, Zhuang, Yaqiang, Qin, Qinghong, Huang, Zhen, Mo, Junyang, Tan, Qixing, Lian, Bin, Cao, Yiming, Qin, Shuting, Wei, Changyuan
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 4820
container_issue 4
container_start_page 4813
container_title Oncology letters
container_volume 15
creator Huang, Jiapeng
Mo, Qinguo
Zhuang, Yaqiang
Qin, Qinghong
Huang, Zhen
Mo, Junyang
Tan, Qixing
Lian, Bin
Cao, Yiming
Qin, Shuting
Wei, Changyuan
description Although nipple-sparing mastectomy (NSM) is being used more frequently, the oncological safety of NSM remains unclear, particularly in young patients (0.05). Following adjustment for clinical stage, the LR and DFS rates between the two groups exhibited no significant differences. Analysis of the prognostic factors demonstrated that clinical stage, lymph node status, estrogen and progesterone receptor status and human epidermal growth factor receptor 2 status were associated with DFS (P
doi_str_mv 10.3892/ol.2018.7913
format Article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5835917</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A535030807</galeid><sourcerecordid>A535030807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-5ac4cb525f4984d8233f39b7dc04ac5e10904863666e5860e95fedd3a634717f3</originalsourceid><addsrcrecordid>eNpdkk1r3DAQhk1paEKaW89FUCg91BvJ-rB0KYSQtIVALulZaOXxroIsuZKdsv31ldlkk1QXiZln3vnQVNUHgldUquY8-lWDiVy1itA31QlpVVMTLJu3h3fLjquznO9xOVwQKcW76rhRnJGG8ZPq722w0ceNs8ajbHqYdij2KLhx9FDn0SQXNmgweQI7xWGHXEC7OBfbaCYHYcroj5u2aJ2gMMiaYCEhG4cSCd3eZ2N4KKSLoeR4lnpfHfXGZzh7vE-rX9dXd5c_6pvb7z8vL25qy1oy1dxYZte84T1TknWyobSnat12FjNjORCsMJOCCiGAS4FB8R66jhpBS3zb09Pq2153nNcDdLaUkozXY3KDSTsdjdOvPcFt9SY-aC4pV6QtAl8eBVL8PUOe9OCyBe9NgDhnXX6AEYYFVwX99B96H-dU-l6oBrOCtuKZ2hgP2oU-lrx2EdUXnHJMscRL2s8vqC0YP21z9PMyyPwa_LoHbYo5J-gPvRGslzXR0S9FSr2sScE_vpzHAX5aCvoPtRu45w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2020420176</pqid></control><display><type>article</type><title>Oncological safety of nipple-sparing mastectomy in young patients with breast cancer compared with conventional mastectomy</title><source>Spandidos Publications Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Huang, Jiapeng ; Mo, Qinguo ; Zhuang, Yaqiang ; Qin, Qinghong ; Huang, Zhen ; Mo, Junyang ; Tan, Qixing ; Lian, Bin ; Cao, Yiming ; Qin, Shuting ; Wei, Changyuan</creator><creatorcontrib>Huang, Jiapeng ; Mo, Qinguo ; Zhuang, Yaqiang ; Qin, Qinghong ; Huang, Zhen ; Mo, Junyang ; Tan, Qixing ; Lian, Bin ; Cao, Yiming ; Qin, Shuting ; Wei, Changyuan</creatorcontrib><description>Although nipple-sparing mastectomy (NSM) is being used more frequently, the oncological safety of NSM remains unclear, particularly in young patients (&lt;35 years). The aim of the present study was to compare the rates of local recurrence (LR), disease-free survival (DFS) and overall survival (OS) in young patients with breast cancer who had undergone NSM or conventional mastectomy (CM). The clinicopathological data of young patients with stage 0-IIB breast cancer who had undergone NSM (163 cases) or CM (194 cases) between 2007 and 2016 were retrospectively analyzed. The log-rank test was used to analyze the differences in the LR, DFS and OS rates between the two groups and multivariate analysis was used to analyze the patient prognostic factors for DFS. The median follow-up time was 49 months. Patients who had undergone CM were more likely to exhibit stage II disease (68.4 vs. 58.3%; P=0.015) and positive lymph nodes (45.9 vs. 33.1%; P=0.014). In the NSM group, LR occurred in 7 (4.3%) cases, systemic recurrence in 15 (9.2%) cases and mortality in 9 (5.5%) cases. In the CM group, LR occurred in 6 (3.1%) cases, systemic recurrence in 27 (13.9%) cases and mortality in 15 (7.7%) cases. There were no statistical differences in the LR, DFS and OS rates between the two groups (P&gt;0.05). Following adjustment for clinical stage, the LR and DFS rates between the two groups exhibited no significant differences. Analysis of the prognostic factors demonstrated that clinical stage, lymph node status, estrogen and progesterone receptor status and human epidermal growth factor receptor 2 status were associated with DFS (P&lt;0.05). NSM is safe for young patients with early-stage breast cancer and provides patients with an improved cosmetic outcome. Furthermore, nipple-areola complex preservation does not increase the risk of recurrence.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2018.7913</identifier><identifier>PMID: 29541245</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Age ; Biopsy ; Breast cancer ; Cancer therapies ; Care and treatment ; Comparative analysis ; Epidermal growth factor ; Health aspects ; Lymphatic system ; Mammography ; Mastectomy ; Medical prognosis ; Metastasis ; Mortality ; Multivariate analysis ; Oncology ; Patients ; Quality of life ; Studies ; Surgery ; Survival analysis</subject><ispartof>Oncology letters, 2018-04, Vol.15 (4), p.4813-4820</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright: © Huang et al. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-5ac4cb525f4984d8233f39b7dc04ac5e10904863666e5860e95fedd3a634717f3</citedby><cites>FETCH-LOGICAL-c471t-5ac4cb525f4984d8233f39b7dc04ac5e10904863666e5860e95fedd3a634717f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835917/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835917/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29541245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Jiapeng</creatorcontrib><creatorcontrib>Mo, Qinguo</creatorcontrib><creatorcontrib>Zhuang, Yaqiang</creatorcontrib><creatorcontrib>Qin, Qinghong</creatorcontrib><creatorcontrib>Huang, Zhen</creatorcontrib><creatorcontrib>Mo, Junyang</creatorcontrib><creatorcontrib>Tan, Qixing</creatorcontrib><creatorcontrib>Lian, Bin</creatorcontrib><creatorcontrib>Cao, Yiming</creatorcontrib><creatorcontrib>Qin, Shuting</creatorcontrib><creatorcontrib>Wei, Changyuan</creatorcontrib><title>Oncological safety of nipple-sparing mastectomy in young patients with breast cancer compared with conventional mastectomy</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Although nipple-sparing mastectomy (NSM) is being used more frequently, the oncological safety of NSM remains unclear, particularly in young patients (&lt;35 years). The aim of the present study was to compare the rates of local recurrence (LR), disease-free survival (DFS) and overall survival (OS) in young patients with breast cancer who had undergone NSM or conventional mastectomy (CM). The clinicopathological data of young patients with stage 0-IIB breast cancer who had undergone NSM (163 cases) or CM (194 cases) between 2007 and 2016 were retrospectively analyzed. The log-rank test was used to analyze the differences in the LR, DFS and OS rates between the two groups and multivariate analysis was used to analyze the patient prognostic factors for DFS. The median follow-up time was 49 months. Patients who had undergone CM were more likely to exhibit stage II disease (68.4 vs. 58.3%; P=0.015) and positive lymph nodes (45.9 vs. 33.1%; P=0.014). In the NSM group, LR occurred in 7 (4.3%) cases, systemic recurrence in 15 (9.2%) cases and mortality in 9 (5.5%) cases. In the CM group, LR occurred in 6 (3.1%) cases, systemic recurrence in 27 (13.9%) cases and mortality in 15 (7.7%) cases. There were no statistical differences in the LR, DFS and OS rates between the two groups (P&gt;0.05). Following adjustment for clinical stage, the LR and DFS rates between the two groups exhibited no significant differences. Analysis of the prognostic factors demonstrated that clinical stage, lymph node status, estrogen and progesterone receptor status and human epidermal growth factor receptor 2 status were associated with DFS (P&lt;0.05). NSM is safe for young patients with early-stage breast cancer and provides patients with an improved cosmetic outcome. Furthermore, nipple-areola complex preservation does not increase the risk of recurrence.</description><subject>Age</subject><subject>Biopsy</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Epidermal growth factor</subject><subject>Health aspects</subject><subject>Lymphatic system</subject><subject>Mammography</subject><subject>Mastectomy</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Oncology</subject><subject>Patients</subject><subject>Quality of life</subject><subject>Studies</subject><subject>Surgery</subject><subject>Survival analysis</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkk1r3DAQhk1paEKaW89FUCg91BvJ-rB0KYSQtIVALulZaOXxroIsuZKdsv31ldlkk1QXiZln3vnQVNUHgldUquY8-lWDiVy1itA31QlpVVMTLJu3h3fLjquznO9xOVwQKcW76rhRnJGG8ZPq722w0ceNs8ajbHqYdij2KLhx9FDn0SQXNmgweQI7xWGHXEC7OBfbaCYHYcroj5u2aJ2gMMiaYCEhG4cSCd3eZ2N4KKSLoeR4lnpfHfXGZzh7vE-rX9dXd5c_6pvb7z8vL25qy1oy1dxYZte84T1TknWyobSnat12FjNjORCsMJOCCiGAS4FB8R66jhpBS3zb09Pq2153nNcDdLaUkozXY3KDSTsdjdOvPcFt9SY-aC4pV6QtAl8eBVL8PUOe9OCyBe9NgDhnXX6AEYYFVwX99B96H-dU-l6oBrOCtuKZ2hgP2oU-lrx2EdUXnHJMscRL2s8vqC0YP21z9PMyyPwa_LoHbYo5J-gPvRGslzXR0S9FSr2sScE_vpzHAX5aCvoPtRu45w</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Huang, Jiapeng</creator><creator>Mo, Qinguo</creator><creator>Zhuang, Yaqiang</creator><creator>Qin, Qinghong</creator><creator>Huang, Zhen</creator><creator>Mo, Junyang</creator><creator>Tan, Qixing</creator><creator>Lian, Bin</creator><creator>Cao, Yiming</creator><creator>Qin, Shuting</creator><creator>Wei, Changyuan</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180401</creationdate><title>Oncological safety of nipple-sparing mastectomy in young patients with breast cancer compared with conventional mastectomy</title><author>Huang, Jiapeng ; Mo, Qinguo ; Zhuang, Yaqiang ; Qin, Qinghong ; Huang, Zhen ; Mo, Junyang ; Tan, Qixing ; Lian, Bin ; Cao, Yiming ; Qin, Shuting ; Wei, Changyuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-5ac4cb525f4984d8233f39b7dc04ac5e10904863666e5860e95fedd3a634717f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Biopsy</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Comparative analysis</topic><topic>Epidermal growth factor</topic><topic>Health aspects</topic><topic>Lymphatic system</topic><topic>Mammography</topic><topic>Mastectomy</topic><topic>Medical prognosis</topic><topic>Metastasis</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>Oncology</topic><topic>Patients</topic><topic>Quality of life</topic><topic>Studies</topic><topic>Surgery</topic><topic>Survival analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>Huang, Jiapeng</creatorcontrib><creatorcontrib>Mo, Qinguo</creatorcontrib><creatorcontrib>Zhuang, Yaqiang</creatorcontrib><creatorcontrib>Qin, Qinghong</creatorcontrib><creatorcontrib>Huang, Zhen</creatorcontrib><creatorcontrib>Mo, Junyang</creatorcontrib><creatorcontrib>Tan, Qixing</creatorcontrib><creatorcontrib>Lian, Bin</creatorcontrib><creatorcontrib>Cao, Yiming</creatorcontrib><creatorcontrib>Qin, Shuting</creatorcontrib><creatorcontrib>Wei, Changyuan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Jiapeng</au><au>Mo, Qinguo</au><au>Zhuang, Yaqiang</au><au>Qin, Qinghong</au><au>Huang, Zhen</au><au>Mo, Junyang</au><au>Tan, Qixing</au><au>Lian, Bin</au><au>Cao, Yiming</au><au>Qin, Shuting</au><au>Wei, Changyuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oncological safety of nipple-sparing mastectomy in young patients with breast cancer compared with conventional mastectomy</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>15</volume><issue>4</issue><spage>4813</spage><epage>4820</epage><pages>4813-4820</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Although nipple-sparing mastectomy (NSM) is being used more frequently, the oncological safety of NSM remains unclear, particularly in young patients (&lt;35 years). The aim of the present study was to compare the rates of local recurrence (LR), disease-free survival (DFS) and overall survival (OS) in young patients with breast cancer who had undergone NSM or conventional mastectomy (CM). The clinicopathological data of young patients with stage 0-IIB breast cancer who had undergone NSM (163 cases) or CM (194 cases) between 2007 and 2016 were retrospectively analyzed. The log-rank test was used to analyze the differences in the LR, DFS and OS rates between the two groups and multivariate analysis was used to analyze the patient prognostic factors for DFS. The median follow-up time was 49 months. Patients who had undergone CM were more likely to exhibit stage II disease (68.4 vs. 58.3%; P=0.015) and positive lymph nodes (45.9 vs. 33.1%; P=0.014). In the NSM group, LR occurred in 7 (4.3%) cases, systemic recurrence in 15 (9.2%) cases and mortality in 9 (5.5%) cases. In the CM group, LR occurred in 6 (3.1%) cases, systemic recurrence in 27 (13.9%) cases and mortality in 15 (7.7%) cases. There were no statistical differences in the LR, DFS and OS rates between the two groups (P&gt;0.05). Following adjustment for clinical stage, the LR and DFS rates between the two groups exhibited no significant differences. Analysis of the prognostic factors demonstrated that clinical stage, lymph node status, estrogen and progesterone receptor status and human epidermal growth factor receptor 2 status were associated with DFS (P&lt;0.05). NSM is safe for young patients with early-stage breast cancer and provides patients with an improved cosmetic outcome. Furthermore, nipple-areola complex preservation does not increase the risk of recurrence.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>29541245</pmid><doi>10.3892/ol.2018.7913</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1792-1074
ispartof Oncology letters, 2018-04, Vol.15 (4), p.4813-4820
issn 1792-1074
1792-1082
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5835917
source Spandidos Publications Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects Age
Biopsy
Breast cancer
Cancer therapies
Care and treatment
Comparative analysis
Epidermal growth factor
Health aspects
Lymphatic system
Mammography
Mastectomy
Medical prognosis
Metastasis
Mortality
Multivariate analysis
Oncology
Patients
Quality of life
Studies
Surgery
Survival analysis
title Oncological safety of nipple-sparing mastectomy in young patients with breast cancer compared with conventional mastectomy
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T14%3A17%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oncological%20safety%20of%20nipple-sparing%20mastectomy%20in%20young%20patients%20with%20breast%20cancer%20compared%20with%20conventional%20mastectomy&rft.jtitle=Oncology%20letters&rft.au=Huang,%20Jiapeng&rft.date=2018-04-01&rft.volume=15&rft.issue=4&rft.spage=4813&rft.epage=4820&rft.pages=4813-4820&rft.issn=1792-1074&rft.eissn=1792-1082&rft_id=info:doi/10.3892/ol.2018.7913&rft_dat=%3Cgale_pubme%3EA535030807%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2020420176&rft_id=info:pmid/29541245&rft_galeid=A535030807&rfr_iscdi=true