Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study, the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study

Homocysteine (Hcy) is a heritable biomarker for CVD, peripheral artery disease, stroke, and dementia. Little is known about genetic associations with Hcy in individuals of African ancestry. We performed a genome-wide association study for Hcy in 4927 AAs from the Jackson Heart Study (JHS), the Multi...

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Veröffentlicht in:	Journal of human genetics 2018-03, Vol.63 (3), p.327-337
Hauptverfasser:	Raffield, Laura M, Ellis, Jaclyn, Olson, Nels C, Duan, Qing, Li, Jin, Durda, Peter, Pankratz, Nathan, Keating, Brendan J, Wassel, Christina L, Cushman, Mary, Wilson, James G, Gross, Myron D, Tracy, Russell P, Rich, Stephen S, Reiner, Alex P, Li, Yun, Willis, Monte S, Lange, Ethan M, Lange, Leslie A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Arteriosclerosis Atherosclerosis Atherosclerosis - blood Atherosclerosis - epidemiology Atherosclerosis - genetics Black or African American - genetics Coronary artery Coronary Artery Disease - blood Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Coronary vessels Dementia disorders Female Females Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genotype Homocysteine Homocysteine - blood Humans Longitudinal Studies Male Middle Aged Mississippi - epidemiology NOX4 protein Polymorphism, Single Nucleotide Population genetics Population Surveillance Quantitative Trait Loci Quantitative Trait, Heritable Sex Vascular diseases Young Adult Young adults
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Zusammenfassung:	Homocysteine (Hcy) is a heritable biomarker for CVD, peripheral artery disease, stroke, and dementia. Little is known about genetic associations with Hcy in individuals of African ancestry. We performed a genome-wide association study for Hcy in 4927 AAs from the Jackson Heart Study (JHS), the Multi-Ethnic Study of Atherosclerosis (MESA), and the Coronary Artery Risk in Young Adults (CARDIA) study. Analyses were stratified by sex and results were meta-analyzed within and across sex. In the sex-combined meta-analysis, we observed genome-wide significant evidence (p
ISSN:	1434-5161 1435-232X 1435-232X
DOI:	10.1038/s10038-017-0384-9