Prognostic Value of Serial N-Terminal Pro-Brain Natriuretic Peptide Testing in Patients With Acute Myocardial Infarction

Prognostic Value of Serial N-Terminal Pro-Brain Natriuretic Peptide Testing in Patients With Acute Myocardial Infarction

Natriuretic peptides (NPs) are important predictors of outcomes in patients with acute myocardial infarction (AMI) but can change over time. The association of patterns of NP changes after AMI on outcomes is less clear. We measured N-terminal pro-brain natriuretic peptide (NT-proBNP) during the AMI...

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Veröffentlicht in:The American journal of cardiology 2017-07, Vol.120 (2), p.181-185
Hauptverfasser: Kontos, Michael C., MD, Lanfear, David E., MD, Gosch, Kensey, MS, Daugherty, Stacie L., MD, Heidenriech, Paul, MD, Spertus, John A., MD
Format: Artikel
Sprache:eng
Schlagworte:
Age
Biomarkers - blood
Brain
Brain natriuretic peptide
Cardiovascular
Diabetes mellitus
Female
Follow-Up Studies
Health risk assessment
Health risks
Heart attacks
Humans
Laboratories
Male
Medical prognosis
Middle Aged
Mortality
Myocardial infarction
Myocardial Infarction - blood
Myocardial Infarction - mortality
Natriuretic Peptide, Brain - blood
Patient Readmission - trends
Patients
Peptide Fragments - blood
Peptides
Prognosis
Prospective Studies
Registries
Risk
Risk Assessment
Survival Rate - trends
Time Factors
United States - epidemiology
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Zusammenfassung:Natriuretic peptides (NPs) are important predictors of outcomes in patients with acute myocardial infarction (AMI) but can change over time. The association of patterns of NP changes after AMI on outcomes is less clear. We measured N-terminal pro-brain natriuretic peptide (NT-proBNP) during the AMI admission and at 1 month in a prospective AMI registry. Outcomes included 1-year readmission and 2-year mortality. An elevated NT-proBNP was defined using age-specific criteria. Patients were classified into 3 groups (low/low [referent group], high/low, high/high) based on NT-proBNP value at enrollment and 1 month. The incremental predictive value of NT-proBNP was determined after adjusting for 6-month GRACE risk score, diabetes, and ejection fraction
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2017.04.004