Genomic Landscape of Pheochromocytoma and Paraganglioma

Recent comprehensive molecular analysis allowed the identification of unique molecular signatures in pheochromocytomas (PHEOs) and paragangliomas (PGLs). Here we summarize the main pathway clusters activated by PHEO- and PGL-susceptibility genes: pseudohypoxic, kinase, and Wnt signaling. Molecular c...

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Veröffentlicht in:	Trends in Cancer 2018-01, Vol.4 (1), p.6-9
Hauptverfasser:	Jochmanova, Ivana, Pacak, Karel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - genetics Adrenal Gland Neoplasms - pathology Genomics Humans Molecular Targeted Therapy Mutation Paraganglioma - genetics Paraganglioma - pathology Paraganglioma - therapy Pheochromocytoma - genetics Pheochromocytoma - pathology Pheochromocytoma - therapy Precision Medicine Signal Transduction - genetics Wnt Proteins - genetics
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Zusammenfassung:	Recent comprehensive molecular analysis allowed the identification of unique molecular signatures in pheochromocytomas (PHEOs) and paragangliomas (PGLs). Here we summarize the main pathway clusters activated by PHEO- and PGL-susceptibility genes: pseudohypoxic, kinase, and Wnt signaling. Molecular characterization and clustering of PHEOs and PGLs may help in the application of principles of personalized medicine and in decision making for targeted therapy of these tumors.
ISSN:	2405-8033 2405-8025
DOI:	10.1016/j.trecan.2017.11.001