Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit

Purpose The Sepsis-3 consensus task force defined sepsis as life-threatening organ dysfunction caused by dysregulated host response to infection. However, the clinical criteria for this definition were neither designed for nor validated in children. We validated the performance of SIRS, age-adapted...

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Veröffentlicht in:	Intensive care medicine 2018-02, Vol.44 (2), p.179-188
Hauptverfasser:	Schlapbach, Luregn J., Straney, Lahn, Bellomo, Rinaldo, MacLaren, Graeme, Pilcher, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Analysis Anesthesiology Australia Child Child, Preschool Children Criteria Critical Care Medicine Emergency Medicine Health risks Hospital Mortality Humans Infant Infection Infections Intensive Intensive care Intensive Care Units Medical prognosis Medical research Medicine Medicine & Public Health Medicine, Experimental Mortality New Zealand Organ Dysfunction Scores Original Pain Medicine Patient outcomes Patients Pediatrics Pneumology/Respiratory System Prognosis Prospective Studies Retrospective Studies Sepsis Sepsis - diagnosis Sepsis - mortality Systemic Inflammatory Response Syndrome Task forces
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Zusammenfassung:	Purpose The Sepsis-3 consensus task force defined sepsis as life-threatening organ dysfunction caused by dysregulated host response to infection. However, the clinical criteria for this definition were neither designed for nor validated in children. We validated the performance of SIRS, age-adapted SOFA, quick SOFA and PELOD-2 scores as predictors of outcome in children. Methods We performed a multicentre binational cohort study of patients
ISSN:	0342-4642 1432-1238
DOI:	10.1007/s00134-017-5021-8