Type II‑C CRISPR-Cas9 Biology, Mechanism, and Application

Genome editing technologies have been revolutionized by the discovery of prokaryotic RNA-guided defense system called CRISPR-Cas. Cas9, a single effector protein found in type II CRISPR systems, has been at the heart of this genome editing revolution. Nearly half of the Cas9s discovered so far belon...

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Veröffentlicht in:	ACS chemical biology 2018-02, Vol.13 (2), p.357-365
Hauptverfasser:	Mir, Aamir, Edraki, Alireza, Lee, Jooyoung, Sontheimer, Erik J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria - enzymology Bacteria - genetics Bacterial Proteins - metabolism CRISPR-Associated Proteins - chemistry CRISPR-Associated Proteins - metabolism CRISPR-Cas Systems - genetics Endonucleases - chemistry Endonucleases - metabolism Gene Editing - methods Protein Domains RNA, Guide, CRISPR-Cas Systems - chemistry RNA, Guide, CRISPR-Cas Systems - genetics
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