Enhancing the Stability and Immunomodulatory Activity of Liposomal Spherical Nucleic Acids through Lipid‐Tail DNA Modifications

Enhancing the Stability and Immunomodulatory Activity of Liposomal Spherical Nucleic Acids through Lipid‐Tail DNA Modifications

Liposomal spherical nucleic acids (LSNAs) are an attractive therapeutic platform for gene regulation and immunomodulation due to their biocompatibility, chemically tunable structures, and ability to enter cells rapidly without the need for ancillary transfection agents. Such structures consist of sm...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2018-02, Vol.14 (5), p.n/a
Hauptverfasser: Meckes, Brian, Banga, Resham J., Nguyen, SonBinh T., Mirkin, Chad A.
Format: Artikel
Sprache:eng
Schlagworte:
Adjuvants, Immunologic - chemistry
Adjuvants, Immunologic - pharmacology
Anchoring
Biocompatibility
Biological activity
Biological properties
biological stability
Cell Line
Cellular structure
Cholesterol
Deoxyribonucleic acid
DNA
DNA - chemistry
Fluorescence
FRET
Gene expression
Immune system
immunomodulation
Lipids
Lipids - chemistry
liposomal spherical nucleic acids
Liposomes
Nanotechnology
Nucleic acids
Nucleic Acids - chemistry
Nucleic Acids - pharmacology
Oligonucleotides
Proteins
Serum proteins
SNA
Transfection
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Zusammenfassung:Liposomal spherical nucleic acids (LSNAs) are an attractive therapeutic platform for gene regulation and immunomodulation due to their biocompatibility, chemically tunable structures, and ability to enter cells rapidly without the need for ancillary transfection agents. Such structures consist of small (
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201702909