MHCI promotes developmental synapse elimination and aging-related synapse loss at the vertebrate neuromuscular junction

Highlights • MHCI immune proteins are expressed at the vertebrate neuromuscular junction (NMJ). • Lower MHCI levels disrupt synapse weakening and elimination at the developing NMJ. • MHCI is involved in synapse elimination specifically over the second postnatal week. • MHCI protein levels rise at th...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-08, Vol.56, p.197-208
Hauptverfasser:	Tetruashvily, Mazell M, McDonald, Marin A, Frietze, Karla K, Boulanger, Lisa M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Allergy and Immunology Animals Animals, Newborn Denervation Development Genes, MHC Class I - physiology Major histocompatibility complex class I MHCI Mice Neuromuscular junction Neuromuscular Junction - growth & development Neuromuscular Junction - metabolism NMJ Psychiatry Synapse elimination Synapses - physiology
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Beschreibung
Zusammenfassung:	Highlights • MHCI immune proteins are expressed at the vertebrate neuromuscular junction (NMJ). • Lower MHCI levels disrupt synapse weakening and elimination at the developing NMJ. • MHCI is involved in synapse elimination specifically over the second postnatal week. • MHCI protein levels rise at the aging NMJ. • Reducing MHCI expression ameliorates aging-related muscle denervation.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.01.008