Expression of sirtuins 1, 6, tumor necrosis factor, and interferon-γ in psoriatic patients

Sirtuins (SIRT) have been regarded as culprits in the pathogenesis of various diseases. Their exact role has not been explained. This study aimed to assess the expression of SIRT1, SIRT6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ in psoriatic patients. Thirty psoriatic patients and 22 co...

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Veröffentlicht in:	International journal of immunopathology and pharmacology 2016-12, Vol.29 (4), p.764-768
Hauptverfasser:	Rasheed, H, El-Komy, MHM, Hegazy, RA, Gawdat, HI, AlOrbani, AM, Shaker, OG
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Case-Control Studies Female Humans Interferon Interferon-gamma - metabolism Letters to the Editor Male Middle Aged Necrosis Pathogenesis Psoriasis Psoriasis - metabolism SIRT1 protein Sirtuin 1 - metabolism Sirtuins Sirtuins - metabolism Skin - metabolism Skin diseases Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Young Adult γ-Interferon
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Zusammenfassung:	Sirtuins (SIRT) have been regarded as culprits in the pathogenesis of various diseases. Their exact role has not been explained. This study aimed to assess the expression of SIRT1, SIRT6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ in psoriatic patients. Thirty psoriatic patients and 22 controls were enrolled. Clinical examination and Psoriasis Area and Severity Index (PASI) were obtained. Two skin biopsies (lesional, peri-lesional) and one from controls were obtained. Tissue levels of SIRT1, SIRT6, TNF-α, and IFN-γ were measured using ELISA. SIRT1 was significantly lower in lesional skin with gradual increase in perilesional followed by control skin (P
ISSN:	2058-7384 0394-6320 2058-7384
DOI:	10.1177/0394632016662475