Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9) virus infection in ferrets

Highlights • VLP vaccine elicited high-titer antibodies specific for A/Anhui/1/2013 H7N9 virus. • VLP-immunized ferrets displayed protection against H7N9 virus. • H7N9 VLP vaccine was effective in protecting against lung and tracheal infection. • ISCOMATRIX or Matrix-M1 adjuvant improved protection...

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Veröffentlicht in:	Vaccine 2015-04, Vol.33 (18), p.2152-2158
Hauptverfasser:	Liu, Ye V, Massare, Michael J, Pearce, Melissa B, Sun, Xiangjie, Belser, Jessica A, Maines, Taronna R, Creager, Hannah M, Glenn, Gregory M, Pushko, Peter, Smith, Gale E, Tumpey, Terrence M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Allergy and Immunology Animals Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Avian influenza China Cholesterol - immunology Cloning Disease Models, Animal Drug Combinations Ferret Ferrets Hemagglutination Inhibition Tests Hemagglutinin Glycoproteins, Influenza Virus - immunology Humans Immunization Immunogenicity Infections Influenza Influenza A Virus, H7N9 Subtype - genetics Influenza A Virus, H7N9 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - prevention & control Manufacturing Mustela Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Pandemics Phospholipids - immunology Public health Respiratory distress syndrome Saponins - immunology Vaccination Vaccine Vaccines Vaccines, Virus-Like Particle - administration & dosage Vaccines, Virus-Like Particle - immunology Viral Load Virus Viruses
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Beschreibung
Zusammenfassung:	Highlights • VLP vaccine elicited high-titer antibodies specific for A/Anhui/1/2013 H7N9 virus. • VLP-immunized ferrets displayed protection against H7N9 virus. • H7N9 VLP vaccine was effective in protecting against lung and tracheal infection. • ISCOMATRIX or Matrix-M1 adjuvant improved protection of the VLP vaccine.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.03.009