Extracellular matrix and traumatic brain injury

Extracellular matrix and traumatic brain injury

The brain extracellular matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell‐cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize t...

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Veröffentlicht in:Journal of neuroscience research 2018-04, Vol.96 (4), p.573-588
Hauptverfasser: George, Naijil, Geller, Herbert M.
Format: Artikel
Sprache:eng
Schlagworte:
Axon guidance
Brain
Cell interactions
Extracellular matrix
Head injuries
hyaluronan
laminin
metalloprotease
proteoglycans
Recovery of function
Regeneration
tenascin
Traumatic brain injury
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Zusammenfassung:The brain extracellular matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell‐cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize the changes in the composition of the ECM as well as how these changes either promote or inhibit recovery of function following traumatic brain injury (TBI). Modulation of ECM composition to facilitates neuronal survival, regeneration and axonal outgrowth is a potential therapeutic target for TBI treatment.
ISSN:0360-4012
1097-4547
DOI:10.1002/jnr.24151