Replication timing kept in LINE

Replication timing kept in LINE

Accurate and synchronous replication timing between chromosome homologues is essential for maintaining chromosome stability, yet how this is achieved has remained a mystery. In this issue, Platt et al. (2018. https://doi.org/10.1083/jcb.201707082) identify antisense LINE (L1) transcripts within long...

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Veröffentlicht in:The Journal of cell biology 2018-02, Vol.217 (2), p.441-443
Hauptverfasser: O'Neill, Rachel J, O'Neill, Michael J
Format: Artikel
Sprache:eng
Schlagworte:
Antisense RNA
Chromosomes
Commentaries
Deactivation
Homology
Inactivation
Replication
Ribonucleic acid
RNA
Stability
Transcription factors
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Zusammenfassung:Accurate and synchronous replication timing between chromosome homologues is essential for maintaining chromosome stability, yet how this is achieved has remained a mystery. In this issue, Platt et al. (2018. https://doi.org/10.1083/jcb.201707082) identify antisense LINE (L1) transcripts within long noncoding RNAs as the critical factor in maintaining synchronous chromosome-wide replication timing.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.201712173