Efficacy of parainfluenza virus 5 (PIV5)-based tuberculosis vaccines in mice

Highlights • We developed a novel TB vaccine that is as effective as BCG in mice. • Using BCG-prime and novel-vaccine boost, we further enhanced efficacy of the vaccine candidates. • We have for the first time shown that PIV5 is effective as a vaccine vector for bacteria pathogen.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2015-12, Vol.33 (51), p.7217-7224
Hauptverfasser:	Chen, Zhenhai, Gupta, Tuhina, Xu, Pei, Phan, Shannon, Pickar, Adrian, Yau, Wilson, Karls, Russell K, Quinn, Frederick D, Sakamoto, Kaori, He, Biao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - genetics Acyltransferases - immunology adults aerosols Allergy and Immunology Animals Antigen 85A Antigen 85B Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Avian flu Bacterial Proteins - genetics Bacterial Proteins - immunology BCG Candidates Clinical trials Colony Count, Microbial Disease Models, Animal Drug Carriers Female Genes Genomes humans immune response Immunogenicity Infections influenza Lung - microbiology lungs Mammalian orthorubulavirus 5 mice Mice, Inbred BALB C Mycobacteria tuberculosis Mycobacterium bovis Mycobacterium tuberculosis Parainfluenza virus Parainfluenza virus 5 Parainfluenza Virus 5 - genetics Paramyxovirus Pathogens Proteins rabies Respiratory syncytial virus Treatment Outcome Tuberculosis Tuberculosis - prevention & control Tuberculosis Vaccines - administration & dosage Tuberculosis Vaccines - genetics Tuberculosis Vaccines - immunology Vaccine Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vectors (Biology) Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • We developed a novel TB vaccine that is as effective as BCG in mice. • Using BCG-prime and novel-vaccine boost, we further enhanced efficacy of the vaccine candidates. • We have for the first time shown that PIV5 is effective as a vaccine vector for bacteria pathogen.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.10.124