A systematic review and meta-analysis: Association between MGMT hypermethylation and the clinicopathological characteristics of non-small-cell lung carcinoma

The relationship between O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and clinicopathological characteristics of non-small-cell lung carcinoma (NSCLC) has remained controversial and unclear. Therefore, in this study we have undertaken a systematic review and meta-analysis of r...

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Veröffentlicht in:	Scientific reports 2018-01, Vol.8 (1), p.1439-11, Article 1439
Hauptverfasser:	Chen, Lin, Wang, Yong, Liu, Fen, Xu, Liyao, Peng, Feifei, Zhao, Ning, Fu, Biqi, Zhu, Zijie, Shi, Yu, Liu, Jiansheng, Wu, Renrui, Wang, Chen, Yao, Shengmin, Li, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 631/67/1612/1350 631/67/395 DNA methylation DNA methyltransferase Humanities and Social Sciences Lung cancer Lung carcinoma Meta-analysis Methylguanine Minority & ethnic groups multidisciplinary Non-small cell lung carcinoma O6-methylguanine-DNA methyltransferase Science Science (multidisciplinary) Smoking Studies Systematic review
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Zusammenfassung:	The relationship between O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and clinicopathological characteristics of non-small-cell lung carcinoma (NSCLC) has remained controversial and unclear. Therefore, in this study we have undertaken a systematic review and meta-analysis of relevant studies to quantitatively investigate this association. We identified 30 eligible studies investigating 2714 NSCLC patients. The relationship between MGMT hypermethylation and NSCLC was identified based on 20 studies, including 1539 NSCLC patient tissue and 1052 normal and adjacent tissue samples (OR = 4.60, 95% CI = 3.46~6.11, p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-018-19949-z