Granulomatosis with polyangiitis: an unusual cause of acute liver injury

Granulomatosis with polyangiitis (GPA) causing liver injury is rare. Where liver biopsies have been taken findings are not always typical and diagnosis can be challenging. Here, we present a case of a 58-year-old male who on admission to hospital was found to have acute liver injury. Diagnosis of li...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BMJ case reports 2018-01, Vol.2018, p.bcr-2017-222464
Hauptverfasser:	Rees, David Owen, Gunavardhan, Anu, Glover, David Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease - epidemiology Antigens Arthritis Case reports Disease Granulomatosis with Polyangiitis - complications Granulomatosis with Polyangiitis - diagnosis Granulomatosis with Polyangiitis - pathology Hepatitis Humans Immunoglobulins Immunologic Factors - therapeutic use Inflammatory diseases Liver Liver - injuries Liver - pathology Liver Diseases - drug therapy Liver Diseases - etiology Liver Diseases - pathology Liver Function Tests - methods Male Medical prognosis Middle Aged Mortality Phosphatase Proteins Rare Disease Rare Diseases Rheumatology Rituximab - administration & dosage Rituximab - therapeutic use Treatment Outcome Ultrasonic imaging Vein & artery diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Granulomatosis with polyangiitis (GPA) causing liver injury is rare. Where liver biopsies have been taken findings are not always typical and diagnosis can be challenging. Here, we present a case of a 58-year-old male who on admission to hospital was found to have acute liver injury. Diagnosis of liver involvement in GPA is supported by liver histology and the resolution of hepatitis after commencement of immunosuppressive treatment.
ISSN:	1757-790X 1757-790X
DOI:	10.1136/bcr-2017-222464