Comparison of FOLFOX and DOF regimens as first-line treatment in East Asian patients with advanced gastric cancer

Our study retrospectively assesses the safety and efficacy of the FOLFOX (oxaliplatin, fluorouracil, and leucovorin) versus DOF (docetaxel, oxaliplatin, and fluorouracil) regimens in untreated locally advanced gastric cancer (AGC). A total of 108 patients underwent DOF (N=58) and FOLFOX (N=50) regim...

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Veröffentlicht in:	OncoTargets and therapy 2018-01, Vol.11, p.375-381
Hauptverfasser:	Liu, Mengyao, Hu, Guofang, Wang, Yuan, Guo, Jun, Liu, Liyan, Han, Xiao, Wang, Zhehai
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Blood Cancer Cancer patients Cancer research Cancer therapies Care and treatment Chemotherapy Comparative analysis Elderly Elderly patients Folinic acid Gastric cancer Hematology Hospitals Medical ethics Medical prognosis Medical records Metastasis Neutropenia Original Research Patients Quality of life Response rates Stomach cancer Studies Thrombocytopenia Toxicity
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Zusammenfassung:	Our study retrospectively assesses the safety and efficacy of the FOLFOX (oxaliplatin, fluorouracil, and leucovorin) versus DOF (docetaxel, oxaliplatin, and fluorouracil) regimens in untreated locally advanced gastric cancer (AGC). A total of 108 patients underwent DOF (N=58) and FOLFOX (N=50) regimens. The end points were overall response rate (ORR), survival, and toxicity. Kaplan-Meier curve was used to estimate overall survival (OS) and progression-free survival (PFS) and Cox regression for multivariate analysis. The ORRs were 50% for DOF and 30% for FOLFOX groups (
ISSN:	1178-6930 1178-6930
DOI:	10.2147/OTT.S149624