Cadherin 17 is related to recurrence and poor prognosis of cytokeratin 19-positive hepatocellular carcinoma

Cadherin 17 is related to recurrence and poor prognosis of cytokeratin 19-positive hepatocellular carcinoma

A previous study demonstrated that cytokeratin 19 (CK19) expression in hepatocellular carcinoma (HCC) is an indicator of HCC invasiveness, including lymph node metastasis (LNM), tumor infiltration/non-encapsulation and poor prognosis. The exact mechanism by which CK19 expression results in poor prog...

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Veröffentlicht in:Oncology letters 2018-01, Vol.15 (1), p.559-567
Hauptverfasser: Lee, Chao-Wei, Lin, Sey-En, Tsai, Hsin-I, Su, Po-Jung, Hsieh, Chia-Hsun, Kuo, Yung-Chia, Sung, Chang-Mu, Lin, Cheng-Yu, Tsai, Chi-Neu, Yu, Ming-Chin
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Cadherins
Cancer recurrence
Care and treatment
Confidence intervals
Development and progression
Gangrene
Gene expression
Genetic aspects
Health aspects
Hepatitis
Hepatocellular carcinoma
Immunoglobulins
Liver cancer
Lymphatic system
Medical prognosis
Metastasis
Multivariate analysis
Oncology
Pathogenesis
Retention
Risk factors
Statistical analysis
Variables
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Zusammenfassung:A previous study demonstrated that cytokeratin 19 (CK19) expression in hepatocellular carcinoma (HCC) is an indicator of HCC invasiveness, including lymph node metastasis (LNM), tumor infiltration/non-encapsulation and poor prognosis. The exact mechanism by which CK19 expression results in poor prognosis remains unclear. Through the use of an Affymetrix U133A oligonucleotide microarray [20 patients with hepatitis B virus (HBV)-HCC], it was demonstrated that cadherin 17 (CDH17) significantly correlated with CK19 expression (R , 0.867; P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2017.7320