Hyaluronan content governs tissue stiffness in pancreatic islet inflammation

We have identified a novel role for hyaluronan (HA), an extracellular matrix polymer, in governing the mechanical properties of inflamed tissues. We recently reported that insulitis in type 1 diabetes of mice and humans is preceded by intraislet accumulation of HA, a highly hygroscopic polymer. Usin...

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Veröffentlicht in:The Journal of biological chemistry 2018-01, Vol.293 (2), p.567-578
Hauptverfasser: Nagy, Nadine, de la Zerda, Adi, Kaber, Gernot, Johnson, Pamela Y., Hu, Kenneth H., Kratochvil, Michael J., Yadava, Koshika, Zhao, Wenting, Cui, Yi, Navarro, Guadalupe, Annes, Justin P., Wight, Thomas N., Heilshorn, Sarah C., Bollyky, Paul L., Butte, Manish J.
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Sprache:eng
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