Graph-theoretical analysis of resting-state fMRI in pediatric obsessive–compulsive disorder

Graph-theoretical analysis of resting-state fMRI in pediatric obsessive–compulsive disorder

Abstract Background fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. Methods Whole-brain resting-state fMRI was acquired at 3 T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local gra...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of affective disorders 2016-03, Vol.193, p.175-184
Hauptverfasser: Armstrong, Casey C, Moody, Teena D, Feusner, Jamie D, McCracken, James T, Chang, Susanna, Levitt, Jennifer G, Piacentini, John C, O’Neill, Joseph
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Case-Control Studies
Cerebral Cortex - physiopathology
Child
Female
fMRI graph theory
Frontal pole
Functional Neuroimaging
Humans
Magnetic Resonance Imaging
Male
Neural Pathways - physiopathology
Obsessive-compulsive disorder
Obsessive-Compulsive Disorder - physiopathology
Psychiatry
Rest
Sensorimotor cortex
Supplementary motor cortex
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract Background fMRI graph theory reveals resting-state brain networks, but has never been used in pediatric OCD. Methods Whole-brain resting-state fMRI was acquired at 3 T from 21 children with OCD and 20 age-matched healthy controls. BOLD connectivity was analyzed yielding global and local graph-theory metrics across 100 child-based functional nodes. We also compared local metrics between groups in frontopolar, supplementary motor, and sensorimotor cortices, regions implicated in recent neuroimaging and/or brain stimulation treatment studies in OCD. Results As in adults, the global metric small-worldness was significantly ( P
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2015.12.071