Effect of home exposure to Staphylococcus aureus on asthma in adolescents

Outcomes in adolescents Subjective symptoms were assessed through three 2-week symptom recall questions (higher symptom report indicates worse asthma) and the Asthma Control Test, which is a set of questions over a 4-week recall (lower score indicates worse asthma).E3,E4 Objective measures of respiratory health were assessed by using Feno, a measure of pulmonary inflammationE5; FEV1; and FEV1/forced vital capacity ratio.E6 History of eczema Insufficient serum was available from a pretreatment visit in the ACE study to test for SE-specific IgE. [...]we evaluated a surrogate measure, eczema (atopic dermatitis), that we hypothesized could be associated with responsiveness to S aureus. Portions of this work were presented previously at the American Academy of Allergy, Asthma & Immunology 2016 conference.E31 Table I Adjusted associations between continuous S aureus and SE log gene copy number per gram of home dust and respiratory symptoms, an inflammatory biomarker, and lung function in ACE trial adolescents Adjusted for age, sex, race/ethnicity, annual income of $15,000 or less, smoking exposure, number of positive skin test results, and recommended treatment step.ACT, Asthma Control Test; FVC, forced vital capacity; OR, odds ratio. Outcome S aureus (n = 424) SEA (n = 424) SEB (n = 424) SEC (n = 415) Total SE (SEA + SEB + SEC) Symptoms Reduced activity in past 2 wk (OR) 0.99 (0.95 to 1.03) 1.12 (1.07 to 1.16)‖ 1.10 (1.06 to 1.13)‖ 1.07 (1.03 to 1.10)‖ 1.05 (1.03 to 1.06)‖ Nights woken by asthma in past 2 wk (OR) 1.01 (0.95 to 1.06) 1.05 (1.00 to 1.11) 1.03 (0.98 to 1.09) 1.07 (1.03 to 1.12)§ 1.03 (1.01 to 1.05)§ Wheeze in past 2 wk (OR) 0.98 (0.95 to 1.01) 1.02 (0.99 to 1.06) 1.01 (0.98 to 1.04) 0.99 (0.96 to 1.02) 1.00 (0.99 to 1.01) ACT Score (β)∗ 0.00 (−0.13 to 0.14) −0.13 (−0.28 to 0.01) −0.13 (−0.27 to 0.01) −0.08 (−0.21 to 0.06) −0.06 (−0.12 to 0.00)‡ Inflammatory biomarkers and lung function Feno (β) 0.01 (−0.03 to 0.05) −0.02 (−0.06 to 0.02) −0.01 (−0.05 to 0.03) −0.01 (−0.04 to 0.03) −0.01 (−0.02 to 0.01) FEV1 (% predicted [β])∗† 0.43 (−0.22 to 1.09) 0.84 (0.16 to 1.53)‡ 0.67 (0.01 to 1.33)‡ 0.47 (−0.18 to 1.14) 0.32 (0.05 to 0.61)‡ FEV1/FVC (% [β])∗† 0.13 (−0.22 to 0.49) 0.40 (0.02 to 0.78)‡ 0.16 (−0.20 to 0.53) 0.16 (−0.21 to 0.53) 0.13 (−0.02 to 0.29) Table E5 Adjusted associations between continuous S aureus and SE log gene copy number per gram of home dust and respiratory symptoms, an inflammatory biomarker, and lung function in ACE trial adolesc