IntOGen-mutations identifies cancer drivers across tumor types

IntOGen-mutations is a discovery tool for cancer researchers to find driver mutations in genes and pathways. The IntOGen-mutations platform ( http://www.intogen.org/mutations/ ) summarizes somatic mutations, genes and pathways involved in tumorigenesis. It identifies and visualizes cancer drivers, a...

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Veröffentlicht in:Nature methods 2013-11, Vol.10 (11), p.1081-1082
Hauptverfasser: Gonzalez-Perez, Abel, Perez-Llamas, Christian, Deu-Pons, Jordi, Tamborero, David, Schroeder, Michael P, Jene-Sanz, Alba, Santos, Alberto, Lopez-Bigas, Nuria
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Sprache:eng
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Zusammenfassung:IntOGen-mutations is a discovery tool for cancer researchers to find driver mutations in genes and pathways. The IntOGen-mutations platform ( http://www.intogen.org/mutations/ ) summarizes somatic mutations, genes and pathways involved in tumorigenesis. It identifies and visualizes cancer drivers, analyzing 4,623 exomes from 13 cancer sites. It provides support to cancer researchers, aids the identification of drivers across tumor cohorts and helps rank mutations for better clinical decision-making.
ISSN:1548-7091
1548-7105
1548-7105
DOI:10.1038/nmeth.2642