Mechanism and regulation of the Lys6-selective deubiquitinase USP30

Structural and biochemical analyses of human USP30 explain the basis of Lys6-linkage preference and regulation by PINK1 and Parkin, shedding light onto how USP30 can act as a brake on mitophagy. Damaged mitochondria undergo mitophagy, a specialized form of autophagy that is initiated by the protein...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature structural & molecular biology 2017-11, Vol.24 (11), p.920-930
Hauptverfasser:	Gersch, Malte, Gladkova, Christina, Schubert, Alexander F, Michel, Martin A, Maslen, Sarah, Komander, David
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 631/45/612/1240 631/45/612/645 631/535/1266 631/80/39 Autophagy Biochemistry Biological Microscopy Chains Crystal structure Deubiquitinating Enzymes - chemistry Deubiquitinating Enzymes - metabolism Dismantling Drug development Genetic regulation Humans Interfaces Kinases Life Sciences Membrane Biology Mitochondria Mitochondrial Proteins - chemistry Mitochondrial Proteins - metabolism Parkin protein Phagocytosis Protein Binding Protein kinase Protein Kinases - metabolism Protein Structure Proteins PTEN-induced putative kinase Substrate Specificity Substrates Thiolester Hydrolases - chemistry Thiolester Hydrolases - metabolism Ubiquitin Ubiquitin - chemistry Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Ubiquitin-specific proteinase Ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!