The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA

Dear Editor, Telomere length homeostasis, dictating cellular prolif- erative potential, is crucial for proper cellular function. In addition to the well-known telomere shortening during cell division and lengthening by activation of telomerase or an alternative lengthening of telomeres （ALT） mechani...

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Veröffentlicht in:	Cell research 2018-01, Vol.28 (1), p.130-134
Hauptverfasser:	Zhao, Yaqing, Zhang, Guang, He, Chao, Mei, Yide, Shi, Yunyu, Li, Fudong
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/103/560 631/45/535 631/45/612/1229 631/80/86 Biomedical and Life Sciences Cell Biology CYS2-HIS2 Zinc Fingers Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Humans Letter to the Editor Life Sciences Telomere - chemistry Telomere - metabolism Transcription Factors - chemistry Transcription Factors - metabolism Zinc finger proteins
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Beschreibung
Zusammenfassung:	Dear Editor, Telomere length homeostasis, dictating cellular prolif- erative potential, is crucial for proper cellular function. In addition to the well-known telomere shortening during cell division and lengthening by activation of telomerase or an alternative lengthening of telomeres （ALT） mechanism, telomere length is also subject to regulated rapid deletion events referred to as telomere trimming [1].
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2017.141