Fatal SV40‐associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque

Recrudescence of latent and dormant viruses may lead to overwhelming viremia in immunosuppressed hosts. In immunocompromised hosts, Simian virus 40 (SV40) reactivation is known to cause nephritis and demyelinating central nervous system disease. Here, we report SV40 viremia leading to fatal intersti...

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Veröffentlicht in:	Journal of medical primatology 2018-02, Vol.47 (1), p.81-84
Hauptverfasser:	Song, M., Mulvihill, M.S., Williams, K.D., Collins, B.H., Kirk, A.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central nervous system Demyelination Immunocompromised Host Immunocompromised hosts Kidney Diseases - physiopathology Kidney Diseases - virology Kidney Transplantation - veterinary Kidneys Macaca mulatta Monkey Diseases - physiopathology Monkey Diseases - virology Monkeys & apes Nephritis Nephropathy opportunistic infection Pneumonia Pneumonia - physiopathology Pneumonia - virology Polyomavirus Infections - complications Polyomavirus Infections - veterinary renal transplant rhesus macaque Simian virus 40 - physiology SV40 Transplantation Tumor Virus Infections - complications Tumor Virus Infections - veterinary viral reactivation Viremia
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Zusammenfassung:	Recrudescence of latent and dormant viruses may lead to overwhelming viremia in immunosuppressed hosts. In immunocompromised hosts, Simian virus 40 (SV40) reactivation is known to cause nephritis and demyelinating central nervous system disease. Here, we report SV40 viremia leading to fatal interstitial pneumonia in an immunosuppressed host following renal allotransplantation.
ISSN:	0047-2565 1600-0684
DOI:	10.1111/jmp.12285