Lessons from ten years of genome‐wide association studies of asthma

Lessons from ten years of genome‐wide association studies of asthma

Twenty‐five genome‐wide association studies (GWAS) of asthma were published between 2007 and 2016, the largest with a sample size of 157242 individuals. Across these studies, 39 genetic variants in low linkage disequilibrium (LD) with each other were reported to associate with disease risk at a sign...

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Veröffentlicht in:Clinical & translational immunology 2017-12, Vol.6 (12), p.e165-n/a
Hauptverfasser: Vicente, Cristina T, Revez, Joana A, Ferreira, Manuel A R
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine
Asthma
Cardiovascular disease
Drug development
Genes
Genetic diversity
Genome-wide association studies
Genomes
Health risk assessment
Linkage disequilibrium
Lupus
Multiple myeloma
Pharmaceuticals
Quantitative trait loci
R&D
Research & development
Review
Rheumatoid arthritis
Thymic stromal lymphopoietin
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Zusammenfassung:Twenty‐five genome‐wide association studies (GWAS) of asthma were published between 2007 and 2016, the largest with a sample size of 157242 individuals. Across these studies, 39 genetic variants in low linkage disequilibrium (LD) with each other were reported to associate with disease risk at a significance threshold of P
ISSN:2050-0068
2050-0068
DOI:10.1038/cti.2017.54