Rare mutations provide unique insight into oncogenic potential of STAT transcription factors

The inappropriate activation of transcription factors, including STATs, is known to promote tumor initiation and progression. The most common mechanisms of misregulation lead to constitutive activation of WT STATs. However, the recent discovery of rare STAT mutations in hematopoietic malignancies su...

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Veröffentlicht in:The Journal of clinical investigation 2018-01, Vol.128 (1), p.113-115
Hauptverfasser: Heppler, Lisa N, Frank, David A
Format: Artikel
Sprache:eng
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