A Retrospective Analysis of Treatment and Clinical Outcomes among Patients with Methicillin-Susceptible Staphylococcus aureus Bloodstream Isolates Possessing Detectable mecA by a Commercial PCR Assay Compared to Patients with Methicillin-Resistant Staphylococcus aureus Bloodstream Isolates

-positive isolates phenotypically susceptible to cefoxitin ( -methicillin-sensitive [MSSA]) have been identified. We describe the treatment and outcomes among patients with -MSSA bloodstream infections (BSI) and MRSA BSI matched 1:1 for age, BSI origin, and BSI type ( = 17 per group). Compared to MRSA BSI patients, -MSSA BSI patients more often experienced clinical failure (58.8% and 11.8%, = 0.010), driven largely by persistent bacteremia (35.3% and 11.8%). -MSSA BSI patients may be at higher risk for poor clinical outcomes.