Roughness and Hydrophilicity as Osteogenic Biomimetic Surface Properties

Successful dental and orthopedic implant outcomes are determined by the degree of osseointegration. Over the last 60 years, endosseous implants have evolved to stimulate osteogenesis without the need for exogenous biologics such as bone morphogenetic proteins. An understanding of the interaction bet...

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Veröffentlicht in:Tissue engineering. Part A 2017-12, Vol.23 (23-24), p.1479-1489
Hauptverfasser: Boyan, Barbara D., Lotz, Ethan M., Schwartz, Zvi
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container_end_page 1489
container_issue 23-24
container_start_page 1479
container_title Tissue engineering. Part A
container_volume 23
creator Boyan, Barbara D.
Lotz, Ethan M.
Schwartz, Zvi
description Successful dental and orthopedic implant outcomes are determined by the degree of osseointegration. Over the last 60 years, endosseous implants have evolved to stimulate osteogenesis without the need for exogenous biologics such as bone morphogenetic proteins. An understanding of the interaction between cells and the physical characteristics of their environments has led to development of bioactive implants. Implant surfaces that mimic the inherent chemistry, topography, and wettability of native bone have shown to provide cells in the osteoblast lineage with the structural cues to promote tissue regeneration and net new bone formation. Studies show that attachment, proliferation, differentiation, and local factor production are sensitive to these implant surface characteristics. This review focuses on how surface properties, including chemistry, topography, and hydrophilicity, modulate protein adsorption, cell behavior, biological reactions, and signaling pathways in peri-implant bone tissue, allowing the development of true biomimetics that promote osseointegration by providing an environment suitable for osteogenesis.
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subjects Acids
Biocompatibility
Biomedical engineering
Biomedical materials
Biomimetics
Bone growth
Bone morphogenetic proteins
Cues
Dental prosthetics
Design
Growth factors
Hydrophilicity
Osseointegration
Osteogenesis
Physical characteristics
Plasma etching
Protein adsorption
Proteins
Regeneration
Regulatory approval
Special Focus
Special Focus Articles
Surface properties
Titanium
Topography
Transplants & implants
Wettability
title Roughness and Hydrophilicity as Osteogenic Biomimetic Surface Properties
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