Blockade of fast A-type and TEA-sensitive potassium channels provide an antiparkinsonian effect in a 6-OHDA animal model

To evaluate the effect of K+ channels inhibitors in treatment of parkinson`s disease (PD). This prospective comparative study was conducted in the Qazvin University of Medical Sciences, Iran, from April 2015 to January 2016. Male rats (n=37) received intraperitoneal doses of TEA (2 and 5 mg/kg) or 4...

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Veröffentlicht in:Neurosciences 2017-01, Vol.22 (1), p.44-50
Hauptverfasser: Haghdoost-Yazdi, Hashem, Piri, Hossein, Najafipour, Reza, Faraji, Ayda, Fraidouni, Negin, Dargahi, Tahereh, Alipour Heidari, Mahmud
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Sprache:eng
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Zusammenfassung:To evaluate the effect of K+ channels inhibitors in treatment of parkinson`s disease (PD). This prospective comparative study was conducted in the Qazvin University of Medical Sciences, Iran, from April 2015 to January 2016. Male rats (n=37) received intraperitoneal doses of TEA (2 and 5 mg/kg) or 4-AP (0.5 and 1 mg/kg) twice-daily, before a stereotactic injection of 6-hydroxydopamine (6-OHDA) for the following 7 days. The 6-OHDA was injected into right medial forebrain bundle (MFB) of the rat brains. Development and severity of PD were assessed using the apomorphine-induced rotational test, the elevated body swing test and rotarod tests. Concentration of malondialdehyde (MDA), a marker of oxidative stress, was measured in rat sera. Tetraethylammonium and 4-AP significantly reduced the number of apomorphine-induced rotations and improved motor learning in the rotarod test at both doses. Administration of 4-AP and TEA together was more effective than single administration of either agent. Malondialdehyde measurement showed that pretreatment with TEA could not prevent 6-OHDA-induced oxidative stress. Our results showed that pretreatment with TEA and 4-AP has a neuroprotective effect against 6-OHDA in dopaminergic neurons in the substantia nigra.
ISSN:1319-6138
1658-3183
1658-3183
DOI:10.17712/nsj.2017.1.20160266