Sofosbuvir‐based regimens for the treatment of chronic hepatitis C in severe renal dysfunction

Sofosbuvir‐based regimens for the treatment of chronic hepatitis C in severe renal dysfunction

Sofosbuvir (SOF) is a nonstructural 5B polymerase inhibitor with activity in all hepatitis C virus (HCV) genotypes and is the backbone of many anti‐HCV drug regimens. SOF is converted into inactive metabolites that undergo renal excretion. Patients with an estimated glomerular filtration rate (eGFR)...

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Veröffentlicht in:Hepatology communications 2017-05, Vol.1 (3), p.248-255
Hauptverfasser: Cox‐North, Paula, Hawkins, Kelsey L., Rossiter, Sean T., Hawley, Marie N., Bhattacharya, Renuka, Landis, Charles S.
Format: Artikel
Sprache:eng
Schlagworte:
Antiviral drugs
Biopsy
Diabetes
Drug dosages
Electrocardiography
Family medical history
FDA approval
Heart failure
Hemodialysis
Hepatitis
Hepatitis C
Hypertension
Kidney diseases
Liver
Liver cirrhosis
Medical records
Mortality
Original
Patients
Studies
Transplants & implants
Ultrasonic imaging
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Zusammenfassung:Sofosbuvir (SOF) is a nonstructural 5B polymerase inhibitor with activity in all hepatitis C virus (HCV) genotypes and is the backbone of many anti‐HCV drug regimens. SOF is converted into inactive metabolites that undergo renal excretion. Patients with an estimated glomerular filtration rate (eGFR) 
ISSN:2471-254X
2471-254X
DOI:10.1002/hep4.1035