Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction

Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction

In a nested case-control study, 1-year posttransplantation surveillance bronchoalveolar lavage (BAL) fluid samples were obtained from incipient CLAD (n = 9) and CLAD-free (n = 8) lung transplant recipients. Differential gene expression analysis, based on an absolute fold change (incipient CLAD vs. n...

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Veröffentlicht in:Annals of the American Thoracic Society 2017-09, Vol.14 (Suppl_3), p.S252-S252
Hauptverfasser: Weigt, S Samuel, Wang, Xiaoyan, Palchevskiy, Vyacheslav, Patel, Naman, Derhovanessian, Ariss, Shino, Michael Y, Sayah, David M, Gregson, Aric L, Lynch, 3rd, Joseph P, Saggar, Rajan, Ross, David J, Ardehali, Abbas, Elashoff, David, Belperio, John A
Format: Artikel
Sprache:eng
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Abstracts
Gene expression
Health risk assessment
Transplants & implants
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Zusammenfassung:In a nested case-control study, 1-year posttransplantation surveillance bronchoalveolar lavage (BAL) fluid samples were obtained from incipient CLAD (n = 9) and CLAD-free (n = 8) lung transplant recipients. Differential gene expression analysis, based on an absolute fold change (incipient CLAD vs. no CLAD) greater than 2.0 and an unadjusted P value not exceeding 0.05, generated a candidate list containing 55 differentially expressed probe sets (51 up-regulated, 4 down-regulated).
ISSN:2329-6933
2325-6621
DOI:10.1513/AnnalsATS.201608-618MG