Genomic imprinting of Xist by maternal H3K27me3

Maternal imprinting at the gene is essential to achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals. However, the mechanism underlying imprinting is unclear. Here we show that the locus is coated with a broad H3K27me3 domain that is established during oocyte...

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Veröffentlicht in:	Genes & development 2017-10, Vol.31 (19), p.1927-1932
Hauptverfasser:	Inoue, Azusa, Jiang, Lan, Lu, Falong, Zhang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blastocyst Embryo, Mammalian Female Gene Expression Regulation, Developmental - genetics Genomic Imprinting - genetics Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Male Mice Oocysts - physiology Research Communication RNA, Long Noncoding - genetics X Chromosome Inactivation - genetics
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Beschreibung
Zusammenfassung:	Maternal imprinting at the gene is essential to achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals. However, the mechanism underlying imprinting is unclear. Here we show that the locus is coated with a broad H3K27me3 domain that is established during oocyte growth and persists through preimplantation development in mice. Loss of maternal H3K27me3 induces maternal expression and maternal XCI in preimplantation embryos. Our study thus identifies maternal H3K27me3 as the imprinting mark of .
ISSN:	0890-9369 1549-5477
DOI:	10.1101/gad.304113.117