Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells

Highlights • Using a tetracycline-inducible lentiviral system, we successfully constructed an in vitro cell model to examine the role of progesterone receptor in non-small cell lung cancer (NSCLC). • We, for the first time, provided direct evidence that PR expression in NSCLC inhibited cell prolifer...

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Veröffentlicht in:	Cancer letters 2016-05, Vol.374 (2), p.279-291
Hauptverfasser:	Kawprasertsri, Sornsawan, Pietras, Richard J, Marguez-Garban, Diana C, Boonyaratanakornkit, Viroj
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell growth Cell Growth Processes - physiology Cell Line, Tumor EGFR Epidermal growth factor Epidermal Growth Factor - antagonists & inhibitors Female HEK293 Cells Hematology, Oncology and Palliative Medicine Humans Kinases Ligands Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology MAPK Medical prognosis Mortality Mutation Progesterone receptor Proline-Rich Protein Domains Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Receptors, Progesterone - biosynthesis Receptors, Progesterone - genetics Receptors, Progesterone - metabolism SH3 domain Signal Transduction Studies Tumors
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Beschreibung
Zusammenfassung:	Highlights • Using a tetracycline-inducible lentiviral system, we successfully constructed an in vitro cell model to examine the role of progesterone receptor in non-small cell lung cancer (NSCLC). • We, for the first time, provided direct evidence that PR expression in NSCLC inhibited cell proliferation. • The polyproline domain in PR was shown to mediate PR inhibition of NSCLC proliferation through impeding with EGFR signal transduction.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.02.014