Zebrafish as a Model to Study Drug Transporters at the Blood-Brain Barrier

The blood–brain barrier (BBB) restricts the delivery of therapeutics into the central nervous system (CNS). This limitation is due largely to localization of drug transport mechanisms to the brain endothelial cells (BECs). Although mammalian and in vitro models are currently used to study drug trans...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2012-11, Vol.92 (5), p.567-570
Hauptverfasser:	Umans, R A, Taylor, M R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport Blood-Brain Barrier - metabolism Brain - metabolism Central Nervous System - metabolism Drug Delivery Systems Endothelial Cells - metabolism Humans Medical sciences Membrane Transport Proteins - metabolism Models, Animal Pharmaceutical Preparations - metabolism Pharmacology. Drug treatments Zebrafish
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Beschreibung
Zusammenfassung:	The blood–brain barrier (BBB) restricts the delivery of therapeutics into the central nervous system (CNS). This limitation is due largely to localization of drug transport mechanisms to the brain endothelial cells (BECs). Although mammalian and in vitro models are currently used to study drug transport, zebrafish (Danio rerio) are advantageous for dissecting complex biological problems such as the BBB. This report focuses on zebrafish as a suitable model system for studying the BBB and drug transport. Clinical Pharmacology & Therapeutics (2012); 92 5, 567–570. doi:10.1038/clpt.2012.168
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2012.168