Airway Mucin Concentration as a Marker of Chronic Bronchitis

Airway Mucin Concentration as a Marker of Chronic Bronchitis

Chronic bronchitis is currently diagnosed by asking patients if they expectorate sputum on a regular basis. In this study, the concentration of mucin was higher in the induced sputum of patients with chronic bronchitis than in those who did not meet the case definition of the disorder.

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Veröffentlicht in:The New England journal of medicine 2017-09, Vol.377 (10), p.911-922
Hauptverfasser: Kesimer, Mehmet, Ford, Amina A, Ceppe, Agathe, Radicioni, Giorgia, Cao, Rui, Davis, C. William, Doerschuk, Claire M, Alexis, Neil E, Anderson, Wayne H, Henderson, Ashley G, Barr, R. Graham, Bleecker, Eugene R, Christenson, Stephanie A, Cooper, Christopher B, Han, MeiLan K, Hansel, Nadia N, Hastie, Annette T, Hoffman, Eric A, Kanner, Richard E, Martinez, Fernando, Paine, Robert, Woodruff, Prescott G, O’Neal, Wanda K, Boucher, Richard C
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Analysis of Variance
Asthma
Asthma - physiopathology
Biomarkers
Biomarkers - analysis
Bronchitis
Bronchitis, Chronic - diagnosis
Bronchitis, Chronic - physiopathology
Chronic obstructive pulmonary disease
Disease Progression
Female
Humans
Lung diseases
Male
Mass Spectrometry
Middle Aged
Mucin
Mucin 5AC - analysis
Mucin-5B - analysis
Mucins - analysis
Mucus
Obstructive lung disease
Pathogenesis
Pulmonary Disease, Chronic Obstructive - physiopathology
Respiratory System - chemistry
Respiratory tract
ROC Curve
Smoking
Smoking - adverse effects
Smoking - physiopathology
Sputum
Sputum - chemistry
Surveys and Questionnaires
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Beschreibung
Zusammenfassung:Chronic bronchitis is currently diagnosed by asking patients if they expectorate sputum on a regular basis. In this study, the concentration of mucin was higher in the induced sputum of patients with chronic bronchitis than in those who did not meet the case definition of the disorder.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa1701632