Long‐term Treatment with Methylene Blue in a Dog with Hereditary Methemoglobinemia Caused by Cytochrome b5 Reductase Deficiency

Long‐term Treatment with Methylene Blue in a Dog with Hereditary Methemoglobinemia Caused by Cytochrome b5 Reductase Deficiency

A juvenile male mixed breed dog was presented for lethargy, exercise intolerance, and aggression when touched on the head. Cyanosis, tachycardia, and tachypnea were observed and persisted during oxygen supplementation. Arterial blood gas analysis by co‐oximetry identified an increased methemoglobin...

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Veröffentlicht in:Journal of veterinary internal medicine 2017-11, Vol.31 (6), p.1860-1865
Hauptverfasser: Jaffey, J.A., Harmon, M.R., Villani, N.A., Creighton, E.K., Johnson, G.S., Giger, U., Dodam, J.R.
Format: Artikel
Sprache:eng
Schlagworte:
aggression
Blood gas
blood gases
Case Report
Cyanosis
CYB5R3
cytochrome b
dog diseases
dogs
enzyme activity
erythrocytes
exercise
head
heterozygosity
juveniles
males
methemoglobinemia
methylene blue
missense mutation
mixed breeds
oxygen
SMALL ANIMAL
tachycardia
tachypnea
Whole‐genome sequence
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Zusammenfassung:A juvenile male mixed breed dog was presented for lethargy, exercise intolerance, and aggression when touched on the head. Cyanosis, tachycardia, and tachypnea were observed and persisted during oxygen supplementation. Arterial blood gas analysis by co‐oximetry identified an increased methemoglobin concentration (27%; normal,
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.14843