Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation

The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D. multiflora) on Shigella flexneri-induced diarrhea in Wistar rats and its subacute toxicity. Diarrhea was induced by oral administration of 1.2 × 109 cells/mL S. flexner...

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Veröffentlicht in:	Evidence-based complementary and alternative medicine 2017-01, Vol.2017 (2017), p.1-9
Hauptverfasser:	Etoa, François-Xavier, Njayou, Frédéric Nico, Njankouo Ndam, Youchahou, Ndoye Foe, Chantal Florentine, Nyegue, Maximilienne A., Afagnigni, Alian D., Fonkoua, Marie-Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Creatinine Developing countries Diarrhea Dissotis Dissotis multiflora Drug dosages Herbal medicine Histology Kidneys Laboratory animals LDCs Leaves Liver Melastomataceae Oral administration Organs Pharmaceuticals Phytochemicals Public health Rats Rodents Shigella Subacute toxicity Toxicity Toxicology
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Zusammenfassung:	The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D. multiflora) on Shigella flexneri-induced diarrhea in Wistar rats and its subacute toxicity. Diarrhea was induced by oral administration of 1.2 × 109 cells/mL S. flexneri to rats. Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg. The level of biochemical parameters was assessed and organs histology examined by 14 days’ subacute toxicity. S. flexneri stool load decreased significantly in dose-dependent manner. The level of ALT increased (p
ISSN:	1741-427X 1741-4288
DOI:	10.1155/2017/4038371