miR-20b promotes cellular proliferation and migration by directly regulating phosphatase and tensin homolog in prostate cancer

miR-20b promotes cellular proliferation and migration by directly regulating phosphatase and tensin homolog in prostate cancer

MicroRNAs are small non-coding RNAs, which are critical regulators of carcinogenesis and tumor progression. Previous studies have identified that microRNA-20b (miR-20b) acts as an oncogene in numerous cancers. However, the role of miR-20b in prostate cancer remains unclear. The present study aimed t...

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Veröffentlicht in:Oncology letters 2017-12, Vol.14 (6), p.6895-6900
Hauptverfasser: Guo, Ju, Xiao, Zewen, Yu, Xingwei, Cao, Runfu
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Breast cancer
Cancer therapies
Care and treatment
Cell growth
Chemotherapy
Deoxyribonucleic acid
Development and progression
DNA
Gene expression
Genetic aspects
Health aspects
Kinases
Metastasis
micro RNAs
MicroRNA
microRNA-20b
Oncology
Phosphatase
phosphatase and tensin homolog
Polymerase chain reaction
Prostate cancer
Studies
Wound healing
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Zusammenfassung:MicroRNAs are small non-coding RNAs, which are critical regulators of carcinogenesis and tumor progression. Previous studies have identified that microRNA-20b (miR-20b) acts as an oncogene in numerous cancers. However, the role of miR-20b in prostate cancer remains unclear. The present study aimed to investigate the expression of miR-20b in prostate cancer and to examine whether modulating miR-20b expression impacts prostate cancer cellular proliferation and migration. It was revealed that miR-20b was strongly expressed in prostate cancer tissues compared with adjacent normal prostate tissues (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2017.7041