Hypothalamic-Pituitary-Adrenal Axis Genetic Variation and Early Stress Moderates Amygdala Function

Highlights • HPA axis genetic profile and early life stress interact to predict amygdala function. • HPA axis genetic profile is associated with anxiety symptoms. • Within system genetic profiles may inform our understanding of psychopathology.

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Bibliographische Detailangaben
Veröffentlicht in:	Psychoneuroendocrinology 2017-06, Vol.80, p.170-178
Hauptverfasser:	Iorio, Christina R. Di, Carey, Caitlin E, Michalski, Lindsay J, Corral-Frias, Nadia S, Conley, Emily Drabant, Hariri, Ahmad R, Bogdan, Ryan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Amygdala Amygdala - physiopathology Anxiety Anxiety - genetics Anxiety Disorders - physiopathology Cortisol Depression Depression - genetics Depressive Disorder - physiopathology Early life stress Emotions - physiology Endocrinology & Metabolism Female Gene Genetic Variation HPA Humans Hypothalamo-Hypophyseal System - metabolism Hypothalamo-Hypophyseal System - physiology Life Change Events Magnetic Resonance Imaging - methods Male Pituitary-Adrenal System - metabolism Pituitary-Adrenal System - physiology Psychiatry Receptors, Corticotropin-Releasing Hormone - genetics Receptors, Corticotropin-Releasing Hormone - metabolism Receptors, Mineralocorticoid - genetics Receptors, Mineralocorticoid - metabolism Stress, Psychological - physiopathology Surveys and Questionnaires Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - metabolism Young Adult
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Beschreibung
Zusammenfassung:	Highlights • HPA axis genetic profile and early life stress interact to predict amygdala function. • HPA axis genetic profile is associated with anxiety symptoms. • Within system genetic profiles may inform our understanding of psychopathology.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2017.03.016