The emerging role of retromer in neuroprotection

Highlights • In the endosomal network retromer retrieves cargo away from the degradative pathway. • Retromer dysfunction has been implicated in Parkinson’s disease through different mechanisms. • These include changes in protein association, protein degradation and mitochondria quality control....

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Veröffentlicht in:	Current opinion in cell biology 2017-08, Vol.47, p.72-82
Hauptverfasser:	McMillan, Kirsty J, Korswagen, Hendrick C, Cullen, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell-Matrix Junctions - metabolism Endosomal Sorting Complexes Required for Transport - metabolism Eukaryotic Cells - metabolism Humans Internal Medicine Neuroprotection Parkinson Disease - metabolism Parkinson Disease - pathology Protein Transport Proteolysis
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • In the endosomal network retromer retrieves cargo away from the degradative pathway. • Retromer dysfunction has been implicated in Parkinson’s disease through different mechanisms. • These include changes in protein association, protein degradation and mitochondria quality control.
ISSN:	0955-0674 1879-0410
DOI:	10.1016/j.ceb.2017.02.004